Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905

被引：37

作者：

Koyama, Nobuhiro ^{[1
]}

Kojima, Shigenobu ^{[1
]}

Nonaka, Kenichi ^{[2
]}

Masuma, Rokuro ^{[2
]}

Matsumoto, Makoto ^{[3
]}

Omura, Satoshi ^{[2
]}

Tomoda, Hiroshi ^{[1
]}

机构：

[1] Kitasato Univ, Grad Sch Pharmaceut Sci, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[3] Otsuka Pharmaceut Co Ltd, Microbiol Res Inst, Kawaguchi, Tokushima, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2010年 / 63卷 / 04期

关键词：

anti-mycobacterial peptide; calpinactam; fungal metabolite; mycobactin; tuberculosis; RESISTANT STAPHYLOCOCCUS-AUREUS; SECRETION SYSTEM INHIBITORS; STREPTOMYCES SP K04-0144; IMIPENEM ACTIVITY; THIOLACTOMYCIN; FERMENTATION; GUADINOMINES; POTENTIATOR; CYSLABDAN; LARIATINS;

D O I：

10.1038/ja.2010.14

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Calpinactam, a new anti-mycobacterial agent, was isolated from the culture broth of a fungal strain Mortierella alpina FKI-4905 by solvent extraction, octadecyl silane column chromatography and preparative HPLC. Calpinactam was active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibited the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 mu g ml(-1), respectively. The Journal of Antibiotics (2010) 63, 183-186; doi:10.1038/ja.2010.14; published online 26 February 2010

引用

页码：183 / 186

页数：4

共 23 条

[1] BASIC LOCAL ALIGNMENT SEARCH TOOL [J].

ALTSCHUL, SF ;

GISH, W ;

MILLER, W ;

MYERS, EW ;

LIPMAN, DJ .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) :403-410

[2] Foreword from the co-editor-in-chief [J].

Brennan, PJ .

TUBERCULOSIS, 2001, 81 (1-2) :1-1

[3]

COLE ST, 1998, NATURE, V6685, P515

[4] Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp FKI-1938 [J].

Fukuda, Takashi ;

Hasegawa, Yoko ;

Sakabe, Yasunari ;

Tomoda, Hiroshi ;

Omura, Satoshi .

JOURNAL OF ANTIBIOTICS, 2008, 61 (09) :550-555

[5] Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp K04-0144 -: II.: Biological activities [J].

Fukumoto, Atsushi ;

Kim, Yong-Pil ;

Hanaki, Hideaki ;

Shiomi, Kazuro ;

Tomoda, Hiroshi ;

Omura, Satoshi .

JOURNAL OF ANTIBIOTICS, 2008, 61 (01) :7-10

[6] Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp K04-0144 -: I.: Taxonomy, fermentation, isolation and structural elucidation [J].

Fukumoto, Atsushi ;

Kim, Yong-Pil ;

Matsumoto, Atsuko ;

Takahashi, Yoko ;

Shiomi, Kazuro ;

Tomoda, Hiroshi ;

Omura, Satoshi .

JOURNAL OF ANTIBIOTICS, 2008, 61 (01) :1-6

[7]

Iwatsuki M, 2008, J ANTIBIOT, V61, P222, DOI 10.1038/ja.2008.32

[8] Guadinomines, type III secretion system inhibitors, produced by Streptomyces sp. K01-0509: II. Physico-chemical properties and structure elucidation [J].

Iwatsuki M. ;

Uchida R. ;

Yoshijima H. ;

Ui H. ;

Shiomi K. ;

Matsumoto A. ;

Takahashi Y. ;

Abe A. ;

Tomoda H. ;

Omura S. .

The Journal of Antibiotics, 2008, 61 (4) :230-236

[9] Lariatins, novel anti-mycobacterial peptides with a lasso structure, produced by Rhodococcus jostii K01-B0171 [J].

Iwatsuki, Masato ;

Uchida, Ryuji ;

Takakusagi, Yoichi ;

Matsumoto, Atsuko ;

Jiang, Cheng-Lin ;

Takahashi, Yoko ;

Arai, Masayoshi ;

Kobayashi, Susumu ;

Matsumoto, Makoto ;

Inokoshi, Junji ;

Tomoda, Hiroshi ;

Omura, Satoshi .

JOURNAL OF ANTIBIOTICS, 2007, 60 (06) :357-363

[10] Lariatins, antimycobacterial peptides produced by Rhodococcus sp K01-B0171, have a lasso structure [J].

Iwatsuki, Masato ;

Tomoda, Hiroshi ;

Uchida, Ryuji ;

Gouda, Hiroaki ;

Hirono, Shuichi ;

Omura, Satoshi .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (23) :7486-7491

← 1 2 3 →