Bioactive flavones and biflavones from Selaginella moellendorffii Hieron

被引：64

作者：

Cao, Yuan ^{[1
]}

Tan, Nin-Hua ^{[3
]}

Chen, Ji-Jun ^{[3
]}

Zeng, Guang-Zhi ^{[3
]}

Ma, Yun-Bao ^{[3
]}

Wu, Yong-Ping ^{[2
]}

Yan, He ^{[3
]}

Yang, Jie ^{[1
]}

Lu, Lai-Feng ^{[1
]}

Wang, Qiang ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Chinese Mat Med Anal, Nanjing 210009, Peoples R China

[2] Jiangsu Prov Inst Mat Med, Nanjing 210009, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

来源：

FITOTERAPIA | 2010年 / 81卷 / 04期

关键词：

Selaginella moellendorffii; Selaginellacea; Flavone; Biflavone; Anti-HBV activity; Cytotoxicity; CYTOTOXIC BIFLAVONOIDS; DOEDERLEINII; DELICATULA;

D O I：

10.1016/j.fitote.2009.09.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new flavones named 5-carboxymethyl-4',7-dihydroxyflavone (1), its ethyl ester (2) and butyl ester (3) were isolated from the herb Selaginella moellendorffii Hieron., together with ten known compounds. Their structures were elucidated on the basis of spectroscopic and chemical analysis. Selected compounds were evaluated for their anti-HBV and cytotoxic activity. Among them, compounds 2 and 3 displayed inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC50 values of 0.17 mg/ml and 0.46 mg/ml, and on HBV e antigen (HBeAg) secretion with IC50 values of 0.42 mg/ml and 0.42 mg/ml, respectively. Compounds 7.8. 10 and 12 exhibited selective cytotoxicity against the three human cancer cell lines tested. (C) 2009 Elsevier By. All rights reserved.

引用

页码：253 / 258

页数：6

共 28 条

[1] The highest-copy repeats are methylated in the small genome of the early divergent vascular plant Selaginella moellendorffii [J].

Chan, Agnes P. ;

Melake-Berhan, Admasu ;

O'Brien, Kimberly ;

Buckley, Stephanie ;

Quan, Hui ;

Chen, Dan ;

Lewis, Matthew ;

Banks, Jo Ann ;

Rabinowicz, Pablo D. .

BMC GENOMICS, 2008, 9 (1)

[2] NEW ALKALOID GLYCOSIDES FROM SELAGINELLA-DOEDERLEINII [J].

CHAO, LR ;

SEGUIN, E ;

TILLEQUIN, F ;

KOCH, M .

JOURNAL OF NATURAL PRODUCTS, 1987, 50 (03) :422-426

[3]

Chen D. Z., 1986, ZHONGCAOYAO, V17, P4

[4] New cytotoxic biflavonoids from Selaginella delicatula [J].

Chen, JJ ;

Duh, CY ;

Chen, JF .

PLANTA MEDICA, 2005, 71 (07) :659-665

[5] EFFECT OF 2-MERCAPTOETHANOL AND MYCOSTATIN ON GUINEA-PIG LYMPHOCYTE-TRANSFORMATION - INTERPRETATION OF RESULTS DEPENDS ON THE METHOD OF CALCULATION [J].

HASLOV, K ;

MOLLER, S ;

BENTZON, MW .

JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 61 (01) :55-65

[6]

Huang Huo-Qiang, 2009, Acta Botanica Yunnanica, V31, P190, DOI 10.3724/SP.J.1143.2009.08199

[7] Osthole increases glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro [J].

Huang, RL ;

Chen, CC ;

Huang, YL ;

Hsieh, DJ ;

Hu, CP ;

Chen, CF ;

Chang, CM .

HEPATOLOGY, 1996, 24 (03) :508-515

[8]

*JIANGS NEW MED CO, 2004, ZHONG YAO DA CI DIAN, P818

[9]

KUNERT O, 2008, PHYTO LETT, V41, P1

[10] Cytotoxic biflavonoids from Selaginella delicatula [J].

Lin, LC ;

Kuo, YC ;

Chou, CJ .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (05) :627-630

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