Cerebellar degeneration and autoimmunity to zinc-finger proteins of the cerebellum

被引：34

作者：

Bataller, L

Wade, DF

Fuller, GN

Rosenfeld, MR

Dalmau, J

机构：

[1] Univ Arkansas Med Sci, Dept Neurol, Little Rock, AR 72205 USA

[2] Univ Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA

[3] Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[4] Cent Arkansas Vet Hlth Care Syst, Little Rock, AR USA

来源：

NEUROLOGY | 2002年 / 59卷 / 12期

关键词：

D O I：

10.1212/01.WNL.0000038352.01415.CE

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The serum of a patient with subacute cerebellar dysfunction was used to probe a cDNA expression library and isolate two genes: Zic1 (zinc-finger of the cerebellum) and Zic4. The patient had intrathecal synthesis of Zic antibodies, suggesting that the Zic proteins were autoantigens of the neurologic disorder. The Zic proteins are involved in cerebellar development and are reported as being preferentially expressed by medulloblastomas. It was found that the expression of Zic proteins is enriched in, but not limited to, medulloblastomas and primitive neuroectodermal tumors.

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页码：1985 / 1987

页数：3

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