Comprehensive assessment of metabolic enzyme and transporter genes using the Affymetrix® Targeted Genotyping System

被引：58

作者：

Dumaual, Carmen

Miao, Xin

Daly, Thomas M.

Bruckner, Carsten

Njau, Reuben

Fu, Dong-Jing

Close-Kirkwood, Sandra

Bauer, Nancy

Watanabe, Nancy

Hardenbol, Paul

Hockett, Richard D. ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA

[2] Affymetrix Inc, Santa Clara, CA 95051 USA

[3] Johnson & Johnson Pharmaceut Res & Dev LLC, Raritan, NJ 08869 USA

[4] Genentech Inc, San Francisco, CA 94080 USA

来源：

PHARMACOGENOMICS | 2007年 / 8卷 / 03期

关键词：

cytochrome P450; drug metabolism; genotyping; molecular inversion probe; multiplex; polymorphism; SNP;

D O I：

10.2217/14622416.8.3.293

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The combined effects of multiple polymorphisms in several drug-metabolizing enzyme and transporter genes can contribute to considerable interindividual variation in drug disposition and response. Therefore, it has been of increasing interest to generate scalable, flexible and cost-effective technologies for large-scale genotyping of the drug-metabolizing enzyme and transporter genes. However, the number of drug-metabolizing enzyme and transporter gene variants exceeds the capacity of current technologies to comprehensively assess multiple polymorphisms in a single, multiplexed assay. The Targeted Genotyping System (Affymetrix(R), CA, USA) provides a solution to this challenge, by combining molecular inversion probe technology with universal microarrays to provide a method that is capable of analyzing thousands of variants in a single reaction, while remaining relatively insensitive to cross-reactivity between reaction components. This review will focus on the Targeted Genotyping System and how this technology was adapted to enable comprehensive analysis of drug-metabolizing enzyme and transporter gene polymorphisms.

引用

页码：293 / 305

页数：13

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