Decreased pulmonary levels of the anti-inflammatory Clara cell 16 kDa protein after induction of airway inflammation in asthmatics

被引：53

作者：

Lensmar, C

Nord, M

Gudmundsson, GH

Roquet, A

Andersson, O

Jörnvall, H

Eklund, A

Grunewald, J

Agerberth, B

机构：

[1] Karolinska Hosp, Dept Med, Div Resp Med, Lung Res Lab, S-17176 Stockholm, Sweden

[2] Huddinge Univ Hosp, Novum, Dept Med Nutr, S-14186 Huddinge, Sweden

[3] Karolinska Inst, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden

[4] Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2000年 / 57卷 / 06期

关键词：

CC16; reverse-phase HPLC; asthma; BAL fluid proteins;

D O I：

10.1007/PL00000738

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Clara cell 16 kDa protein (CC16) maps to an atopy-associated region of chromosome ii and has been ascribed an anti-inflammatory function. Using reverse-phase HPLC and Western blot analysis, we have evaluated the polypeptide pattern in bronchoalveolar lavage (BAL) fluid retrieved from asthmatics, before and after induction of airway inflammation by low-dose allergen inhalation challenge. A prominent decrease of CC16 was seen after induction of inflammation, and a further CC16 decrease was observed in lavage fluid where surfactant had been removed. Reduced levels of pulmonary CC16 may cause loss of anti-inflammatory activity in the airways and contribute to the development of airway inflammation in asthma.

引用

页码：976 / 981

页数：6

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