Highly enantioselective thiourea-catalyzed nitro-Mannich reactions

被引：294

作者：

Yoon, TP ^{[1
]}

Jacobsen, EN ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 03期

关键词：

amines; asymmetric catalysis; diastereoselectivity; enantioselectivity; Mannich reaction;

D O I：

10.1002/anie.200461814

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Approaching privileged" status? A new and highly effective enantioselective catalyst for the nitro-Mannich reaction was identified by modification of thioureabased Strecker catalysts (see scheme). Products are obtained in high enantiomeric purity and up to 16:1 diastereoselectivity."

引用

页码：466 / 468

页数：3

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