Physicochemical, foundations and structural design of hydrogels in medicine and biology

被引：781

作者：

Peppas, NA ^{[1
]}

Huang, Y ^{[1
]}

Torres-Lugo, M ^{[1
]}

Ward, JH ^{[1
]}

Zhang, J ^{[1
]}

机构：

[1] Purdue Univ, Sch Chem Engn, Program Therapeut & Diagnost Devices, Biomat & Drug Delivery Labs, W Lafayette, IN 47907 USA

来源：

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING | 2000年 / 2卷

关键词：

controlled release; diffusion; polymer network; responsive hydrogels; swelling;

D O I：

10.1146/annurev.bioeng.2.1.9

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Hydrogels are cross-linked hydrophilic polymers that can imbibe water or biological fluids. Their biomedical and pharmaceutical applications include a very wide range of systems and processes that utilize several molecular design characteristics. This review discusses the molecular structure, dynamic behavior, and structural modifications of hydrogels as well as the various applications of these biohydrogels. Recent advances in the preparation of three-dimensional structures with exact chain conformations, as well as tethering of functional groups, allow for the preparation of promising new hydrogels. Meanwhile, intelligent biohydrogels with pH- or temperature-sensitivity continue to be important materials in medical applications.

引用

页码：9 / 29

页数：21

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