Retroinverso analogue of the antiviral octapeptide C8 inhibits feline immunodeficiency virus in serum

被引：13

作者：

D'Ursi, AM

Giannecchini, S

Di Fenza, A

Esposito, C

Armenante, MR

Carotenuto, A

Bendinelli, M

Rovero, P ^{[1
]}

机构：

[1] Univ Solerno, Dept Pharmaceut Sci, I-84084 Fisciano, Italy

[2] Univ Pisa, Retrovirus Ctr, I-56127 Pisa, Italy

[3] Univ Pisa, Virol Sect, Dept Expt Pathol, I-56127 Pisa, Italy

[4] Mymetics Corp, Annapolis, MD USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 46卷 / 10期

关键词：

D O I：

10.1021/jm034012h

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We described the antiviral activity of an octapeptide corresponding to a Trp-rich domain of feline immunodeficiency virus (FIV) transmembrane glycoprotein. To overcome the limited enzymatic stability of short peptides, the retroinverso analogue was prepared and tested for inhibitory activity of FIV in the presence or absence of normal cat serum. Differently from the unmodified peptide, the retroinverso analogue maintains strong inhibitory activity in serum. NMR studies showed that it displays crucial conformational features believed to be important for antiviral activity.

引用

页码：1807 / 1810

页数：4

共 43 条

[1] MLEV-17-BASED TWO-DIMENSIONAL HOMONUCLEAR MAGNETIZATION TRANSFER SPECTROSCOPY [J].