Sex-dependent antidepressant effects of lower doses of progesterone in rats

被引:29
作者
Andrade, S. [1 ]
Silveira, S. L. [1 ]
Arbo, B. D. [2 ]
Batista, B. A. M. [1 ]
Gomez, R. [2 ]
Barros, H. M. T. [2 ]
Ribeiro, M. F. M. [1 ]
机构
[1] Univ Fed Rio Grande do Sul, Dept Physiol, ICBS, BR-90050170 Porto Alegre, RS, Brazil
[2] Univ Fed Ciencias Saude Porto Alegre, Div Pharmacol, BR-90050170 Porto Alegre, RS, Brazil
关键词
Forced swim test; Female rats; Estrous cycle; Depression; Gonadal hormones; Gender; FORCED SWIM TEST; GENDER-DIFFERENCES; OVARIECTOMIZED RATS; BEHAVIORAL DESPAIR; FEMALE RATS; DEPRESSION; STRESS; MODEL; MICE; ETHOPHARMACOLOGY;
D O I
10.1016/j.physbeh.2010.02.002
中图分类号
B84 [心理学];
学科分类号
010107 [宗教学];
摘要
Major depression is more prevalent among women than men, and progesterone might be involved in the mechanisms that generate these differences. Progesterone is clinically used for women in several reproductive events, but its antidepressant effect is unclear. Animal studies showed the interference of progesterone on depressive behaviors of rodents, but they are inconclusive, and no study compared different treatment durations. This study investigated the antidepressant effect of low doses of progesterone in male and female rats under acute or chronic administration. Male and female Wistar rats in different phases of the estrous cycle were acutely administered different doses of progesterone (0.0, 0.4. 0.8 and 1.2 mg/kg) and tested in the forced swimming test (FST). The lowest dose of progesterone (0.4 mg/kg) was chronically administered during two complete estrous cycles and diestrous II female and male rats were tested in the FST. Progesterone decreased depressive-like behaviors only in chronically treated diestrous II female rats and increased immobility in male rats. This low dose of progesterone did not interfere in the hormonal cycling in female rats. Results also showed that diestrous II female rats had greater immobility than male rats in the FST. The greater immobility of diestrous II female rats shows that rats in this estrous phase present more depressive-like behaviors that may be associated with their lower serum levels of progesterone. We showed that progesterone chronically administered at low doses reverses these depressive-like behaviors and has an antidepressant effect during the diestrous II phase of the estrous cycle. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:687 / 690
页数:4
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