The functional state of the serotonergic system and the 5-HTTLPR polymorphism of the serotonin transporter gene in patients with schizophrenia

被引：7

作者：

Golimbet, V. E. ^{[1
]}

Korovaitseva, G. I. ^{[1
]}

Brusov, O. S. ^{[1
]}

Faktor, M. I. ^{[1
]}

Ganisheva, T. K. ^{[1
]}

Dmitriev, D. A. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 115552, Russia

来源：

MOLECULAR BIOLOGY | 2010年 / 44卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

serotonin; serotonin transporter; schizophrenia; 5-HTTLPR polymorphism; PLATELETS;

D O I：

10.1134/S0026893310020068

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blood serotonin concentration is implicated in the regulation of behavior as well as in the development of psychopathological symptoms. Serotonin transporter regulates the serotonin level by reuptaking it from the synaptic cleft. In this study, platelet serotonin concentrations and the serotonin binding constant (V (max)) were compared in patients with schizophrenia and healthy individuals with different 5-HTTLPR genotypes. The study included 60 patients and 62 controls. The above biochemical parameters were associated with the 5-HTTLPR genotype. Both in patients and controls, carriers of the LL genotype had lower blood serotonin concentrations and V (max) as compared to those with genotypes containing one or two S alleles. These results suggest that the 5-HTTLPR polymorphism of the serotonin transporter gene is involved in regulating the state of the serotonergic system.

引用

页码：223 / 227

页数：5

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