Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases

被引：361

作者：

Mazanetz, Michael P.

Fischer, Peter M.

机构：

[1] Univ Nottingham, Ctr Biomol Sci, Nottingham NG7 2RD, England

[2] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2007年 / 6卷 / 06期

关键词：

D O I：

10.1038/nrd2111

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aggregation of hyperphosphorylated tau is one of the characteristic neuropathological lesions of Alzheimer's disease and other neurodegenerative disorders. Pharmacological modulation of tau hyperphosphorylation might represent a valid and feasible therapeutic strategy for such disorders. Here, we consider recent evidence supporting the validity of the three most relevant kinases affecting tau hyperphosphorylation - GSK3 beta, CDK5 and ERK2 - as drug targets and describe progress in the design of inhibitors for these kinases.

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页码：464 / 479

页数：16

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