Enhanced ferrite nanoparticles as MRI contrast agents

被引：106

作者：

Shultz, Michael D.

Calvin, Scott

Fatouros, Panos P.

Morrison, Shannon A.

Carpenter, Everett E.

机构：

[1] Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA

[2] Sarah Lawrence Coll, Dept Phys, Bronxville, NY 10708 USA

[3] Virginia Commonwealth Univ, Dept Radiol, Richmond, VA 23284 USA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2007年 / 311卷 / 01期

关键词：

MRI; enhanced ferrite; iron nanoparticle;

D O I：

10.1016/j.jmmm.2006.10.1188

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Enhanced ferrite nanoparticles are a new class of contrast agents for magnetic resonance imaging (MRI). The enhanced ferrites, are synthesized by reverse micelles technique to form iron core and oxide or ferrite shell preventing further oxidation of the nanoparticles. The nanoparticles are further functionalized using dopamine and PEG-600 to increase the solubility of the high magnetic moment nanoparticles. H-1 relaxation measurements of aqueous solutions of the nanoparticles were conducted at 2.4T. The relaxivities r(1) and r(2), representing the slopes of these curves, are 7.19 and 9.96 s(-1) mM(-1), respectively. These values should be compared with relaxivities of 4-5 s(-1) mM(-1) corresponding to commonly used commercial contrast agents in human MR examinations. (C) 2006 Published by Elsevier B.V.

引用

收藏

页码：464 / 468

页数：5

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