共 114 条
The secretases: enzymes with therapeutic potential in Alzheimer disease
被引:619
作者:

De Strooper, Bart
论文数: 0 引用数: 0
h-index: 0
机构:
VIB, Ctr Human Genet, B-3000 Louvain, Belgium
KULeuven, B-3000 Louvain, Belgium VIB, Ctr Human Genet, B-3000 Louvain, Belgium

Vassar, Robert
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Cell & Mol Biol, Chicago, IL 60611 USA VIB, Ctr Human Genet, B-3000 Louvain, Belgium

Golde, Todd
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin Florida, Dept Neurosci, Coll Med, Jacksonville, FL 32224 USA VIB, Ctr Human Genet, B-3000 Louvain, Belgium
机构:
[1] VIB, Ctr Human Genet, B-3000 Louvain, Belgium
[2] KULeuven, B-3000 Louvain, Belgium
[3] Northwestern Univ, Dept Cell & Mol Biol, Chicago, IL 60611 USA
[4] Mayo Clin Florida, Dept Neurosci, Coll Med, Jacksonville, FL 32224 USA
关键词:
AMYLOID PRECURSOR PROTEIN;
GATED SODIUM-CHANNELS;
NECROSIS-FACTOR-ALPHA;
CELL-CELL ADHESION;
GAMMA-SECRETASE;
BETA-SECRETASE;
KINASE-C;
ASPARTYL PROTEASE;
CLEAVING ENZYME;
FAMILY-MEMBERS;
D O I:
10.1038/nrneurol.2009.218
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
The amyloid hypothesis has yielded a series of well-validated candidate drug targets with potential for the treatment of Alzheimer disease (AD). Three proteases that are involved in the processing of amyloid precursor protein-alpha-secretase, beta-secretase and gamma-secretase-are of particular interest as they are central to the generation and modulation of amyloid-beta peptide and can be targeted by small compounds in vitro and in vivo. Given that these proteases also fulfill other important biological roles, inhibiting their activity will clearly be inherently associated with mechanism-based toxicity. Carefully determining a suitable therapeutic window and optimizing the selectivity of the drug treatments towards amyloid precursor protein processing might be ways of overcoming this potential complication. Secretase inhibitors are likely to be the first small-molecule therapies aimed at AD modification that will be fully tested in the clinic. Success or failure of these first-generation AD therapies will have enormous consequences for further drug development efforts for AD and possibly other neurodegenerative conditions.
引用
收藏
页码:99 / 107
页数:9
相关论文
共 114 条
[1]
Dynamics of Aβ Turnover and Deposition in Different β-Amyloid Precursor Protein Transgenic Mouse Models Following γ-Secretase Inhibition
[J].
Abramowski, Dorothee
;
Wiederhold, Karl-Heinz
;
Furrer, Ulrich
;
Jaton, Anne-Lise
;
Neuenschwander, Anton
;
Runser, Marie-Josephine
;
Danner, Simone
;
Reichwald, Julia
;
Ammaturo, Domenico
;
Staab, Dieter
;
Stoeckli, Markus
;
Rueeger, Heinrich
;
Neumann, Ulf
;
Staufenbiel, Matthias
.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,
2008, 327 (02)
:411-424

Abramowski, Dorothee
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Wiederhold, Karl-Heinz
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Furrer, Ulrich
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Jaton, Anne-Lise
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Neuenschwander, Anton
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Runser, Marie-Josephine
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Danner, Simone
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Reichwald, Julia
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Ammaturo, Domenico
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Staab, Dieter
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Stoeckli, Markus
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Rueeger, Heinrich
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Neumann, Ulf
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland

Staufenbiel, Matthias
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Inst BioMed Res, Basel, Switzerland Novartis Inst BioMed Res, Basel, Switzerland
[2]
ADAMs family members as amyloid precursor protein α-secretases
[J].
Allinson, TMJ
;
Parkin, ET
;
Turner, AJ
;
Hooper, NM
.
JOURNAL OF NEUROSCIENCE RESEARCH,
2003, 74 (03)
:342-352

Allinson, TMJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leeds, Sch Biochem & Mol Biol, Proteolysis Res Grp, Leeds LS2 9JT, W Yorkshire, England Univ Leeds, Sch Biochem & Mol Biol, Proteolysis Res Grp, Leeds LS2 9JT, W Yorkshire, England

Parkin, ET
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leeds, Sch Biochem & Mol Biol, Proteolysis Res Grp, Leeds LS2 9JT, W Yorkshire, England Univ Leeds, Sch Biochem & Mol Biol, Proteolysis Res Grp, Leeds LS2 9JT, W Yorkshire, England

Turner, AJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leeds, Sch Biochem & Mol Biol, Proteolysis Res Grp, Leeds LS2 9JT, W Yorkshire, England Univ Leeds, Sch Biochem & Mol Biol, Proteolysis Res Grp, Leeds LS2 9JT, W Yorkshire, England

Hooper, NM
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leeds, Sch Biochem & Mol Biol, Proteolysis Res Grp, Leeds LS2 9JT, W Yorkshire, England Univ Leeds, Sch Biochem & Mol Biol, Proteolysis Res Grp, Leeds LS2 9JT, W Yorkshire, England
[3]
Putative function of ADAM9, ADAM10, and ADAM17 as APP α-secretase
[J].
Asai, M
;
Hattori, C
;
Szabó, B
;
Sasagawa, N
;
Maruyama, K
;
Tanuma, S
;
Ishiura, S
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
2003, 301 (01)
:231-235

Asai, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Life Sci, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan

Hattori, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Life Sci, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan

Szabó, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Life Sci, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan

Sasagawa, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Life Sci, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan

Maruyama, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Life Sci, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan

Tanuma, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Life Sci, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan

Ishiura, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Life Sci, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan
[4]
Role of the APP non-amyloidogenic signaling pathway and targeting α-secretase as an alternative drug target for treatment of Alzheimer's disease
[J].
Bandyopadhyay, S.
;
Goldstein, L. E.
;
Lahiri, D. K.
;
Rogers, J. T.
.
CURRENT MEDICINAL CHEMISTRY,
2007, 14 (27)
:2848-2864

Bandyopadhyay, S.
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Psychiat Neurosci & Genet, Neurochem Lab, Boston, MA 02114 USA
Massachusetts Gen Hosp, Aging Res Unit, Boston, MA USA Massachusetts Gen Hosp, Dept Psychiat Neurosci & Genet, Neurochem Lab, Boston, MA 02114 USA

Goldstein, L. E.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Psychiat Brigham & Womens Hosp, Cambridge, MA 02138 USA Massachusetts Gen Hosp, Dept Psychiat Neurosci & Genet, Neurochem Lab, Boston, MA 02114 USA

Lahiri, D. K.
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Dept Psychiat, Inst Psychiat Res,Lab Mol Neurogenet, Indianapolis, IN 46204 USA Massachusetts Gen Hosp, Dept Psychiat Neurosci & Genet, Neurochem Lab, Boston, MA 02114 USA

Rogers, J. T.
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Psychiat Neurosci & Genet, Neurochem Lab, Boston, MA 02114 USA
Massachusetts Gen Hosp, Aging Res Unit, Boston, MA USA Massachusetts Gen Hosp, Dept Psychiat Neurosci & Genet, Neurochem Lab, Boston, MA 02114 USA
[5]
A γ-Secretase Inhibitor Decreases Amyloid-β Production in the Central Nervous System
[J].
Bateman, Randall J.
;
Siemers, Eric R.
;
Mawuenyega, Kwasi G.
;
Wen, Guolin
;
Browning, Karen R.
;
Sigurdson, Wendy C.
;
Yarasheski, Kevin E.
;
Friedrich, Stuart W.
;
DeMattos, Ronald B.
;
May, Patrick C.
;
Paul, Steven M.
;
Holtzman, David M.
.
ANNALS OF NEUROLOGY,
2009, 66 (01)
:48-54

Bateman, Randall J.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA
Washington Univ, Alzheimers Dis Res Ctr, Sch Med, St Louis, MO 63110 USA
Washington Univ, Hope Ctr Neurol Disorders, Sch Med, St Louis, MO 63110 USA Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA

Siemers, Eric R.
论文数: 0 引用数: 0
h-index: 0
机构:
Eli Lilly & Co, Indianapolis, IN 46285 USA Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA

Mawuenyega, Kwasi G.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA

Wen, Guolin
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA

Browning, Karen R.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA

Sigurdson, Wendy C.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA

Yarasheski, Kevin E.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Dept Med, Sch Med, St Louis, MO 63110 USA Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA

Friedrich, Stuart W.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Alzheimers Dis Res Ctr, Sch Med, St Louis, MO 63110 USA Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA

DeMattos, Ronald B.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Alzheimers Dis Res Ctr, Sch Med, St Louis, MO 63110 USA Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA

May, Patrick C.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Alzheimers Dis Res Ctr, Sch Med, St Louis, MO 63110 USA Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA

Paul, Steven M.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Alzheimers Dis Res Ctr, Sch Med, St Louis, MO 63110 USA Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA

Holtzman, David M.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA
Washington Univ, Alzheimers Dis Res Ctr, Sch Med, St Louis, MO 63110 USA
Washington Univ, Hope Ctr Neurol Disorders, Sch Med, St Louis, MO 63110 USA
Washington Univ, Dept Dev Biol, Sch Med, St Louis, MO 63110 USA Washington Univ, Dept Neurol, Sch Med, St Louis, MO 63110 USA
[6]
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
[J].
Black, RA
;
Rauch, CT
;
Kozlosky, CJ
;
Peschon, JJ
;
Slack, JL
;
Wolfson, MF
;
Castner, BJ
;
Stocking, KL
;
Reddy, P
;
Srinivasan, S
;
Nelson, N
;
Boiani, N
;
Schooley, KA
;
Gerhart, M
;
Davis, R
;
Fitzner, JN
;
Johnson, RS
;
Paxton, RJ
;
March, CJ
;
Cerretti, DP
.
NATURE,
1997, 385 (6618)
:729-733

Black, RA
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Rauch, CT
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Kozlosky, CJ
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Peschon, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Slack, JL
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Wolfson, MF
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Castner, BJ
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Stocking, KL
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Reddy, P
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Srinivasan, S
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Nelson, N
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Boiani, N
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Schooley, KA
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Gerhart, M
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Davis, R
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Fitzner, JN
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Johnson, RS
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Paxton, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

March, CJ
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101

Cerretti, DP
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corporation, Seattle, WA 98101
[7]
Evidence that tumor necrosis factor α converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor
[J].
Buxbaum, JD
;
Liu, KN
;
Luo, YX
;
Slack, JL
;
Stocking, KL
;
Peschon, JJ
;
Johnson, RS
;
Castner, BJ
;
Cerretti, DP
;
Black, RA
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1998, 273 (43)
:27765-27767

Buxbaum, JD
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

Liu, KN
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

Luo, YX
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

Slack, JL
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

Stocking, KL
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

Peschon, JJ
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

Johnson, RS
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

Castner, BJ
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

Cerretti, DP
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

Black, RA
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA
[8]
M1 receptors play a central role in modulating AD-like pathology in transgenic mice
[J].
Caccamo, A
;
Oddo, S
;
Billings, LM
;
Green, KN
;
Martinez-Coria, H
;
Fisher, A
;
LaFerla, FM
.
NEURON,
2006, 49 (05)
:671-682

Caccamo, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Oddo, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Billings, LM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Green, KN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Martinez-Coria, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Fisher, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA

LaFerla, FM
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA
[9]
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
[J].
Cai, HB
;
Wang, YS
;
McCarthy, D
;
Wen, HJ
;
Borchelt, DR
;
Price, DL
;
Wong, PC
.
NATURE NEUROSCIENCE,
2001, 4 (03)
:233-234

Cai, HB
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

Wang, YS
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

McCarthy, D
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

Wen, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

Borchelt, DR
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

Price, DL
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

Wong, PC
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
[10]
Glu332 in the Nicastrin ectodomain is essential for γ-secretase complex maturation but not for its activity
[J].
Chavez-Gutierrez, Lucia
;
Tolia, Alexandra
;
Maes, Elke
;
Li, Tong
;
Wong, Philip C.
;
de Strooper, Bart
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2008, 283 (29)
:20096-20105

Chavez-Gutierrez, Lucia
论文数: 0 引用数: 0
h-index: 0
机构:
Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium
VIB, Dept Mol & Dev Genet, B-3000 Louvain, Belgium Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

Tolia, Alexandra
论文数: 0 引用数: 0
h-index: 0
机构:
Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium
VIB, Dept Mol & Dev Genet, B-3000 Louvain, Belgium Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

Maes, Elke
论文数: 0 引用数: 0
h-index: 0
机构:
Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium
VIB, Dept Mol & Dev Genet, B-3000 Louvain, Belgium Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

Li, Tong
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

Wong, Philip C.
论文数: 0 引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

de Strooper, Bart
论文数: 0 引用数: 0
h-index: 0
机构:
Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium
VIB, Dept Mol & Dev Genet, B-3000 Louvain, Belgium Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium