Ciona intestinalis as a model for cardiac development

被引：87

作者：

Davidson, Brad ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cellular Biol, Div Genet & Dev, Berkeley, CA 94720 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 01期

关键词：

heart development; organogenesis; gene regulation; chordate evolution;

D O I：

10.1016/j.semcdb.2006.12.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The primitive chordate Ciona intestinalis has emerged as a significant model system for the study of heart development. The Ciona embryo employs a conserved heart gene network in the context of extremely low cell numbers and reduced genetic redundancy. Here, I review recent studies on the molecular genetics of Ciona cardiogenesis as well as classic work on heart anatomy and physiology. I also discuss the potential of employing Ciona to decipher a comprehensive chordate gene network and to determine how this network controls heart morphogenesis. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：16 / 26

页数：11

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