The anti-allodynic α2δ ligand pregabalin inhibits the trafficking of the calcium channel α2δ-1 subunit to presynaptic terminals in vivo

被引：75

作者：

Bauer, Claudia S.

Rahman, Wahida

Tran-Van-Minh, Alexandra

Lujan, Rafael ^{[1
]}

Dickenson, Anthony H.

Dolphin, Annette C.

机构：

[1] Univ Castilla La Mancha, Dept Ciencias Med, Albacete 02006, Spain

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2010年 / 38卷

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

alpha(2)delta-1; neuropathic pain; pregabalin; spinal nerve ligation; trafficking; voltage-gated calcium channel; DORSAL-ROOT GANGLION; NEUROPATHIC PAIN; UP-REGULATION; MECHANISMS; CONTRIBUTES; GABAPENTIN; EXPRESSION; HORN;

D O I：

10.1042/BST0380525

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Neuropathic pain is caused by lesion or dysfunction of the peripheral sensory nervous system Up-regulation of the voltage-gated Ca2+ channel subunit alpha(2)delta-1 in DRG (dorsal root ganglion) neurons and the spinal cord correlates with the onset of neuropathic pain symptoms such as allodynia in several animal models of neuropathic pain. The clinically important anti-allodynic drugs gabapentin and pregabalin are alpha(2)delta-1 ligands, but how these drugs alleviate neuropathic pain is poorly understood. In the present paper, we review recent advances in our understanding of their molecular mechanisms.

引用

收藏

页码：525 / 528

页数：4

相关论文

共 24 条

[1]

The Increased Trafficking of the Calcium Channel Subunit α2δ-1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the α2δ Ligand Pregabalin [J].

Bauer, Claudia S. ;

Nieto-Rostro, Manuela ;

Rahman, Wahida ;

Tran-Van-Minh, Alexandra ;

Ferron, Laurent ;

Douglas, Leon ;

Kadurin, Ivan ;

Ranjan, Yorain Sri ;

Fernandez-Alacid, Laura ;

Millar, Neil S. ;

Dickenson, Anthony H. ;

Lujan, Rafael ;

Dolphin, Annette C. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (13) :4076-4088

[2]

Injury discharges regulate calcium channel alpha-2-delta-1 subunit upregulation in the dorsal horn that contributes to initiation of neuropathic pain [J].

Boroujerdi, Amin ;

Kim, Hee Kee ;

Lyu, Yeoung Su ;

Kim, Doo-Sik ;

Figueroa, Katherine W. ;

Chung, Jin Mo ;

Luo, Z. David .

PAIN, 2008, 139 (02) :358-366

[3]

From nociception to pain perception: imaging the spinal and supraspinal pathways [J].

Brooks, J ;

Tracey, I .

JOURNAL OF ANATOMY, 2005, 207 (01) :19-33

[4]

The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of α2δ subunits is key to trafficking voltage-gated Ca2+ channels [J].

Cantí, C ;

Nieto-Rostro, M ;

Foucault, I ;

Heblich, F ;

Wratten, J ;

Richards, MW ;

Hendrich, J ;

Douglas, L ;

Page, KM ;

Davies, A ;

Dolphin, AC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (32) :11230-11235

[5]

Mechanisms of the antinociceptive action of gabapentin [J].

Cheng, Jen-Kun ;

Chiou, Lih-Chu .

JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, 100 (05) :471-486

[6]

Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. [J].

Costigan, Michael ;

Befort, Katia ;

Karchewski, Laurie ;

Griffin, Robert S. ;

D'Urso, Donatella ;

Allchorne, Andrew ;

Sitarski, Joanne ;

Mannion, James W. ;

Pratt, Richard E. ;

Woolf, Clifford J. .

BMC NEUROSCIENCE, 2002, 3 (1)

[7]

Functional biology of the α2δ subunits of voltage-gated calcium channels [J].

Davies, Anthony ;

Hendrich, Jan ;

Van Minh, Alexandra Tran ;

Wratten, Jack ;

Douglas, Leon ;

Dolphin, Annette C. .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2007, 28 (05) :220-228

[8]

Ca2+ channel α2δ ligands:: novel modulators of neurotransmission [J].

Dooley, David J. ;

Taylor, Charles P. ;

Donevan, Sean ;

Feltner, Douglas .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2007, 28 (02) :75-82

[9]

Identification of the α2-δ-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin [J].

Field, Mark J. ;

Cox, Peter J. ;

Stott, Emma ;

Melrose, Heather ;

Offord, James ;

Su, Ti-Zhi ;

Bramwell, Steve ;

Corradini, Laura ;

England, Steven ;

Winks, Joanna ;

Kinloch, Ross A. ;

Hendrich, Jan ;

Dolphin, Annette C. ;

Webb, Tony ;

Williams, Dic .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (46) :17537-17542

[10]

Gordois A., 2003, Diabetes Foot, V6, P62