Hyperglycemia-induced oxidative stress in diabetic complications

被引：413

作者：

King, GL

Loeken, MR

机构：

[1] Joslin Diabet Ctr, Sect Dev & Stem Cell Biol, Boston, MA 02215 USA

[2] Joslin Diabet Ctr, Sect Vasc Cell Biol & Complicat, Boston, MA 02215 USA

[3] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 2004年 / 122卷 / 04期

关键词：

oxidative stress; free radicals; diabetic complications;

D O I：

10.1007/s00418-004-0678-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reactive oxygen species are increased by hyperglycemia. Hyperglycemia, which occurs during diabetes (both type 1 and type 2) and, to a lesser extent, during insulin resistance, causes oxidative stress. Free fatty acids, which may be elevated during inadequate glycemic control, may also be contributory. In this review, we will discuss the role of oxidative stress in diabetic complications. Oxidative stress may be important in diabetes, not just because of its role in the development of complications, but because persistent hyperglycemia, secondary to insulin resistance, may induce oxidative stress and contribute to beta cell destruction in type 2 diabetes. The focus of this review will be on the role of oxidative stress in the etiology of diabetic complications.

引用

收藏

页码：333 / 338

页数：6

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