Chemical transglycosylation of functional bioactive glyco-linkages

被引：17

作者：

Ikeda, T

Kajimoto, T

Kinjo, J

Nakayama, K

Nohara, T

机构：

[1] Kumamoto Univ, Fac Pharmaceut Sci, Kumamoto 862, Japan

[2] Showa Univ, Sch Pharmaceut Sci, Shinagawa Ku, Tokyo 142, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(98)00519-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The natural functional bioactive oligosaccharides moieties, mimosatetraose and fabatriose, were cut off from julibrosides and soyasaponin I by chemical and enzymatic methods, respectively, and were pasted to diosgenin to give neosaponins 1 and 2. The obtained neosaponins were tested for cytotoxicity and hepatoprotective activity. This method could be applied to the synthesis of novel bioactive glycosides. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3513 / 3516

页数：4

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