No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults

被引：57

作者：

Surtees, Paul G.

Wainwright, Nicholas W. J.

Willis-Owen, Saffron A. G.

Sandhu, Manjinder S.

Luben, Robert

Day, Nicholas E.

Flint, Jonathan

机构：

[1] Strangeways Res Lab, Cambridge CB1 8RN, England

[2] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England

[3] Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2007年 / 41卷 / 05期

关键词：

brain-derived neurotrophic factor; generalised anxiety disorder; major depressive disorder; genetic association studies; NEUROTROPHIC-FACTOR BDNF; GENERALIZED ANXIETY DISORDER; FACTOR GENETIC-POLYMORPHISM; FAMILY-BASED ASSOCIATION; LONG-TERM-POTENTIATION; BIPOLAR DISORDER; MAJOR DEPRESSION; MENTAL-HEALTH; PERSONALITY-TRAITS; CODING VARIANT;

D O I：

10.1016/j.jpsychires.2006.01.004

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Recent research has suggested that brain-derived neurotrophic factor (BDNF) may be implicated in the aetiology of mood-related phenotypes. Here we report an investigation of the association between a BDNF coding variant (Val66Met, rs6265) and mood status in a large non-clinical sample of men and women. We genotyped 7389 adult men and women, aged 41-80 years, selected from participants in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk, United Kingdom). Evidence of past year prevalent, lifetime and recurrent episodic major depressive disorder (MDD) and of past year prevalent and lifetime generalised anxiety disorder (GAD), defined by DSM-IV diagnostic criteria, was assessed through questionnaire together with a five-item version of the Mental Health Inventory (MHI-5). A total of 1214 (16.4%) participants reported lifetime MDD and 355 (4.8%) reported lifetime GAD. In this population based study we found no evidence to support an association between the BDNF gene Val66Met polymorphism and mood status. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：404 / 409

页数：6

共 49 条

[1] Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor [J].