Synthesis and antibacterial activity of new poly-S-lysine-porphyrin conjugates

被引：141

作者：

Tomé, JPC

Neves, MGPMS

Tomé, AC

Cavaleiro, JAS

Soncin, M

Magaraggia, M

Ferro, S

Jori, G

机构：

[1] Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal

[2] Univ Padua, Dept Biol, I-35131 Padua, Italy

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 26期

关键词：

D O I：

10.1021/jm040802v

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Studies on the synthesis, structural elucidation, and biological evaluation of new conjugates of poly-S-lysine with meso-substituted porphyrins are described. The new conjugates: were used in the photoinactivation of antibiotic-resistant Gram-positive bacteria (Staphylococcus aureus strains ATCC 25923 and MRSA 110) and Gram-negative bacteria (Escherichia coli strain 04). The results show that the cationic conjugates are able to photosensitize the efficient inactivation of both types of bacteria.

引用

页码：6649 / 6652

页数：4

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