DNA REPAIR Decision at the break point

被引：13

作者：

Boulton, Simon J. ^{[1
]}

机构：

[1] Canc Res UK, London Res Inst, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England

来源：

NATURE | 2010年 / 465卷 / 7296期

关键词：

BRCA1; 53BP1; P53;

D O I：

10.1038/465301a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many decisions affect the fate of damaged DNA — for example, how to repair the damage, or whether to repair it at all and instead let the damaged cell die. An intricate web of molecular interactions affects such decisions.

引用

页码：301 / 302

页数：2

共 9 条

[1] Cellular functions of the BRCA tumour-suppressor proteins [J].

Boulton, S. J. .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2006, 34 :633-645

[2] 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers [J].

Bouwman, Peter ;

Aly, Amal ;

Escandell, Jose M. ;

Pieterse, Mark ;

Bartkova, Jirina ;

van der Gulden, Hanneke ;

Hiddingh, Sanne ;

Thanasoula, Maria ;

Kulkarni, Atul ;

Yang, Qifeng ;

Haffty, Bruce G. ;

Tommiska, Johanna ;

Blomqvist, Carl ;

Drapkin, Ronny ;

Adams, David J. ;

Nevanlinna, Heli ;

Bartek, Jiri ;

Tarsounas, Madalena ;

Ganesan, Shridar ;

Jonkers, Jos .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010, 17 (06) :688-U56

[3] 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks [J].

Bunting, Samuel F. ;

Callen, Elsa ;

Wong, Nancy ;

Chen, Hua-Tang ;

Polato, Federica ;

Gunn, Amanda ;

Bothmer, Anne ;

Feldhahn, Niklas ;

Fernandez-Capetillo, Oscar ;

Cao, Liu ;

Xu, Xiaoling ;

Deng, Chu-Xia ;

Finkel, Toren ;

Nussenzweig, Michel ;

Stark, Jeremy M. ;

Nussenzweig, Andre .

CELL, 2010, 141 (02) :243-254

[4] Senescence aging, and malignant transformation mediated by p53 in mice lacking the Brcal full-length isoform [J].

Cao, L ;

Li, WM ;

Kim, S ;

Brodie, SG ;

Deng, CX .

GENES & DEVELOPMENT, 2003, 17 (02) :201-213

[5] A Selective Requirement for 53BP1 in the Biological Response to Genomic Instability Induced by Brca1 Deficiency [J].

Cao, Liu ;

Xu, Xioaling ;

Bunting, Samuel F. ;

Liu, Jie ;

Wang, Rui-Hong ;

Cao, Longyue L. ;

Wu, J. Julie ;

Peng, Tie-Nan ;

Chen, Junjie ;

Nussenzweig, Andre ;

Deng, Chu-Xia ;

Finkel, Toren .

MOLECULAR CELL, 2009, 35 (04) :534-541

[6] Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks [J].

Galanty, Yaron ;

Belotserkovskaya, Rimma ;

Coates, Julia ;

Polo, Sophie ;

Miller, Kyle M. ;

Jackson, Stephen P. .

NATURE, 2009, 462 (7275) :935-U132

[7] The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress [J].

Morris, Joanna R. ;

Boutell, Chris ;

Keppler, Melanie ;

Densham, Ruth ;

Weekes, Daniel ;

Alamshah, Amin ;

Butler, Laura ;

Galanty, Yaron ;

Pangon, Laurent ;

Kiuchi, Tai ;

Ng, Tony ;

Solomon, Ellen .

NATURE, 2009, 462 (7275) :886-U77

[8] Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis [J].

Xu, XL ;

Qiao, WH ;

Linke, SP ;

Cao, L ;

Li, WM ;

Furth, PA ;

Harris, CC ;

Deng, CX .

NATURE GENETICS, 2001, 28 (03) :266-271

[9] BRCA1 ubiquitinates its phosphorylation-dependent binding partners CtIP [J].

Yu, Xiaochun ;

Fu, Shuang ;

Lai, Maoyi ;

Baer, Richard ;

Chen, Junjie .

GENES & DEVELOPMENT, 2006, 20 (13) :1721-1726

← 1 →