Modulation of K+-induced synaptosomal calcium influx by gabapentin

被引：24

作者：

Meder, WP ^{[1
]}

Dooley, DJ ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Dept Neurosci Therapeut, Ann Arbor, MI 48105 USA

来源：

BRAIN RESEARCH | 2000年 / 875卷 / 1-2期

关键词：

gabapentin; synaptosomes; Fura-PE3; calcium influx; neocortex; rat;

D O I：

10.1016/S0006-8993(00)02610-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gabapentin, a drug useful in several neurological and psychiatric disorders, decreased K+ (15 mM)-induced [Ca2+](i) increase in Fura-PE3-loaded rat neocortical synaptosomes (IC50=9.7 mu M; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca2+ influx in response to depolarizing (pathological) conditions causing excessive neurotransmitter release. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：157 / 159

页数：3

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