Inherited and acquired vulnerability to ventricular arrhythmias:: Cardiac Na+ and K+ channels

被引:72
作者
Clancy, CE
Kass, RS
机构
[1] Cornell Univ, Weill Med Coll, Inst Computat Biomed, Dept Physiol & Biophys, New York, NY 10021 USA
[2] Columbia Univ, Coll Phys & Surg, Dept Pharmacol, New York, NY USA
关键词
D O I
10.1152/physrev.00005.2004
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Mutations in cardiac Na+ and K+ channels can disrupt the precise balance of ionic currents that underlies normal cardiac excitation and relaxation. Disruption of this equilibrium can result in arrhythmogenic phenotypes leading to syncope, seizures, and sudden cardiac death. Congenital defects result in an unpredictable expression of phenotypes with variable penetrance, even within single families. Additionally, phenotypically opposite and overlapping cardiac arrhythmogenic syndromes can stem from one mutation. A number of these defects have been characterized experimentally with the aim of understanding mechanisms of mutation-induced arrhythmia. Improving understanding of abnormalities may provide a basis for the development of therapeutic approaches.
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收藏
页码:33 / 47
页数:15
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