Melanin-concentrating hormone gene-related peptide stimulates ACTH, but not alpha-MSH, release from the tilapia pituitary

被引：4

作者：

Groneveld, D

Balm, PHM

Bonga, SEW

机构：

[1] Department of Animal Physiology, Faculty of Science, University of Nijmegen, 6525 ED Nijmegen, Toernooiveld

来源：

JOURNAL OF ENDOCRINOLOGY | 1996年 / 148卷 / 01期

关键词：

D O I：

10.1677/joe.0.148R001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tilapia (Oreochromis mossambicus; teleostei) melanin-concentrating hormone gene-related peptide (tMgrp) was tested for tropic actions on adenocorticotropin hormone (ACTH) and alpha-melanocyte stimulating hormone (alpha-MSH) producing cells in the tilapia pituitary gland in vitro. Up to 100 mu M synthetic tilapia Mgrp (tMgrp) had no effect on alpha-MSH release from tilapia neurointermediate lobes in a superfusion set up. However, at concentrations above 1 mu M, tMgrp concentration dependently stimulated ACTH release from tilapia anterior lobes. This is the first evidence that Mgrp modulates ACTH release from teleost corticotropes, and this might implicate the peptide in the regulation of the pituitary-interrenal axis of fish.

引用

页码：R1 / R4

页数：4

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