What is the evidence that osteoarthritis is genetically determined?

被引：16

作者：

Cicuttini, FM ^{[1
]}

Spector, TD

机构：

[1] Alfred Hosp, Dept Epidemiol & Prevent Med, Prahran, Vic 3181, Australia

[2] St Thomas Hosp, Twin Res Unit, London SE1 7EH, England

来源：

BAILLIERES CLINICAL RHEUMATOLOGY | 1997年 / 11卷 / 04期

关键词：

osteoarthritis; genetics; inheritance;

D O I：

10.1016/S0950-3579(97)80002-7

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Although for many years it was speculated that osteoarthritis was genetically determined, little data were available to support this contention. A major problem with early work was a lack of consistency in the definition of osteoarthritis. Based on a radiographical definition of osteoarthritis, which is currently the optimal method for epidemiological and genetic studies, data from a recent twin study have provided an estimate of the hereditable component of osteoarthritis to be in the order of 50 to 65%. In addition, sophisticated molecular biology techniques are being increasingly used to explore potential genetic abnormalities in cartilage and matrix components in osteoarthritis. These exciting new data are examined as we address the role of genetic factors in osteoarthritis.

引用

页码：657 / 669

页数：13

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