Characterization of the Manila family of Mycobacterium tuberculosis

被引:50
作者
Douglas, JT
Qian, LS
Montoya, JC
Musser, JM
Van Embden, JDA
Van Soolingen, D
Kremer, K
机构
[1] Univ Hawaii Manoa, Dept Microbiol, Honolulu, HI 96822 USA
[2] Univ Philippines, Res Inst Trop Med, Manila, Philippines
[3] Univ Philippines, Philippine Gen Hosp, Manila, Philippines
[4] NIAID, Lab Human Bacterial Pathogenesis, Rocky Mt Labs, NIH, Hamilton, MT USA
[5] Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands
关键词
D O I
10.1128/JCM.41.6.2723-2726.2003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Forty-eight Mycobacterium tuberculosis strains were obtained from patients living in metropolitan Manila, Republic of the Philippines. Three molecular typing methods, IS6110 restriction fragment length polymorphism, spoligotyping, and DNA sequencing of the oxyR, gyrA, and katG loci, established that these strains have restricted diversity and are members of a related genetic group of organisms. Comparison of the DNA fingerprint patterns with those in international databases confirmed the uniqueness of this group of isolates, which we designate the Manila family of M. tuberculosis.
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收藏
页码:2723 / 2726
页数:4
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