No effect of the CYP1A2*1F genotype on thioridazine, mesoridazine, sulforidazine plasma concentrations in psychiatric patients

被引:4
作者
Dorado, Pedro
Berecz, Roland
Penas-Lledo, Eva M.
de la Rubia, Alfredo
LLerena, Adrian
机构
[1] Extremadura Univ Hosp, CICAB, Clin Res Ctr, Fac Med,Serv Extremeno Salud, E-06071 Badajoz, Spain
[2] Univ Debrecen, Med & Hlth Sci Ctr, Dept Psychiat, Debrecen, Hungary
[3] Merida Psychiat Hosp, Merida, Venezuela
[4] Univ Beira Interior, CICS, Covilha, Portugal
关键词
D O I
10.1007/s00228-007-0284-6
中图分类号
R9 [药学];
学科分类号
1007 [药学];
摘要
引用
收藏
页码:527 / 528
页数:2
相关论文
共 9 条
[1]
Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype [J].
Berecz, R ;
de la Rubia, A ;
Dorado, P ;
Fernández-Salguero, P ;
Dahl, ML ;
Llerena, A .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 59 (01) :45-50
[2]
THE INFLUENCE OF ENVIRONMENTAL AND GENETIC-FACTORS ON CYP2D6, CYP1A2 AND UDP-GLUCURONOSYLTRANSFERASES IN MAN USING SPARTEINE, CAFFEINE, AND PARACETAMOL AS PROBES [J].
BOCK, KW ;
SCHRENK, D ;
FORSTER, A ;
GRIESE, EU ;
MORIKE, K ;
BROCKMEIER, D ;
EICHELBAUM, M .
PHARMACOGENETICS, 1994, 4 (04) :209-218
[3]
Pharmacokinetic interaction of fluvoxamine and thioridazine in schizophrenic patients [J].
Carrillo, JA ;
Ramos, SI ;
Herraiz, AG ;
Llerena, A ;
Agundez, JAG ;
Berecz, R ;
Duran, M ;
Benítez, J .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 1999, 19 (06) :494-499
[4]
Use of the mesoridazine/thioridazine ratio as a marker for CYP2D6 enzyme activity [J].
Llerena, A ;
Berecz, R ;
de la Rubia, A ;
Norberto, MJ ;
Benítez, J .
THERAPEUTIC DRUG MONITORING, 2000, 22 (04) :397-401
[5]
Schizophrenia and tobacco smoking in a Spanish psychiatric hospital [J].
LLerena, A ;
de la Rubia, A ;
Peñas-Lledó, EM ;
Diaz, FJ ;
de Leon, J .
SCHIZOPHRENIA RESEARCH, 2002, 58 (2-3) :323-327
[6]
Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes [J].
Llerena, A ;
Berecz, R ;
de la Rubia, A ;
Fernández-Salguero, P ;
Dorado, P .
THERAPEUTIC DRUG MONITORING, 2001, 23 (06) :616-620
[7]
MacLeod S. L., 1998, Proceedings of the American Association for Cancer Research Annual Meeting, V39, P396
[8]
Functional significance of a C→A polymorphism in intron I of the cytochrome P450 CYP1A2 gene tested with caffeine [J].
Sachse, C ;
Brochmöller, J ;
Bauer, S ;
Roots, I .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1999, 47 (04) :445-449
[9]
Characterization of human cytochrome P450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine [J].
Wojcikowski, J ;
Maurel, P ;
Daniel, WA .
DRUG METABOLISM AND DISPOSITION, 2006, 34 (03) :471-476