COMT Val158Met and BDNF C270T polymorphisms in schizophrenia:: a case-control study

被引：38

作者：

Galderisi, S

Maj, M

Kirkpatrick, B

Piccardi, P

Mucci, A

Invernizzi, G

Rossi, A

Pini, S

Vita, A

Cassano, P

Stratta, P

Severino, G

Del Zompo, M

机构：

[1] Univ Naples Federico II, Dept Psychiat, SUN, I-80138 Naples, Italy

[2] Univ Maryland, Maryland Psychiat Res Ctr, Baltimore, MD 21228 USA

[3] Univ Maryland, Dept Psychiat, Baltimore, MD 21228 USA

[4] Univ Cagliari, Dept Neurosci, Sect Clin Pharmacol, I-09100 Cagliari, Italy

[5] Univ Milan, Dept Psychiat, I-20100 Milan, Italy

[6] Univ Aquila, Dept Psychiat, I-67100 Laquila, Italy

[7] Univ Pisa, Dept Psychiat, I-56100 Pisa, Italy

来源：

SCHIZOPHRENIA RESEARCH | 2005年 / 73卷 / 01期

关键词：

catechol-O-methyl transferase gene; brain-derived neurotrophic factor gene; schizophrenia;

D O I：

10.1016/j.schres.2004.06.017

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In a multicenter study involving 217 subjects of European ancestry [106 patients with schizophrenia and 111 healthy subjects], we tested the hypothesis that the catechol-O-methyl transferase (COMT) Val(158)Met and/or the brain-derived neurotrophic factor (BDNF) (CT)-T-270 gene polymorphisms are associated with schizophrenia. The COMT and BDNF genotype and their allele distribution did not differ between patients with schizophrenia and healthy comparison subjects. These results do not support the hypothesis that the COMT Val(158)Met or BDNF (CT)-T-270 gene polymorphisms are associated with liability to schizophrenia. (C) 2004 Elsevier B.V All rights reserved.

引用

页码：27 / 30

页数：4

共 12 条

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