Host innate immune response to Mycobacterium tuberculosis

被引：201

作者：

Bhatt, Kamlesh ^{[1
]}

Salgame, Padmini ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, Ctr Emerging Pathogens, Newark, NJ 07101 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2007年 / 27卷 / 04期

关键词：

Mycobaterium tuberculosis; innate immunity; TLR2; dendritic cells; macrophages;

D O I：

10.1007/s10875-007-9084-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-gamma-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.

引用

收藏

页码：347 / 362

页数：16

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