RNA virus evolution via a fitness-space model

被引：203

作者：

Tsimring, LS ^{[1
]}

Levine, H ^{[1
]}

Kessler, DA ^{[1
]}

机构：

[1] BAR ILAN UNIV,DEPT PHYS,IL-52900 RAMAT GAN,ISRAEL

来源：

PHYSICAL REVIEW LETTERS | 1996年 / 76卷 / 23期

关键词：

D O I：

10.1103/PhysRevLett.76.4440

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We present a mean-field theory for the evolution of RNA virus populations. The theory operates with a distribution of the population in a one-dimensional fitness space, and is valid for sufficiently smooth fitness landscapes. Our approach explains naturally the recent experimental observation [L. S. Novella et al., Proc. Natl. Acad. Sci. U.S.A. 92, 5841-5844 (1995)] of two distinct stages in the growth of virus fitness.

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页码：4440 / 4443

页数：4

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