The role of modulatory calcineurin-interacting proteins in calcineurin signaling

被引：142

作者：

Rothermel, BA

Vega, RB

Williams, RS

机构：

[1] Univ Texas, Div Cardiol, Dept Internal Med, SW Med Ctr, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

[3] Duke Univ, Sch Med, Off Dean, Durham, NC USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2003年 / 13卷 / 01期

关键词：

D O I：

10.1016/S1050-1738(02)00188-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Modulatory calcineurin-interacting proteins (MCIPs), also known as the Down syndrome critical region 1 (DSCR1) and DSCR1-like proteins, are a recently described family of small, structurally related proteins that are preferentially expressed in heart, skeletal muscle, and brain. MCIP proteins can bind to and inhibit calcineurin, a calcium/calmodulin-regulated serine/threonine protein phosphatase that is activated during cardiac hypertrophy and failure. Transcription of the mammalian MCIP1 gene is induced by calcineurin, suggesting that it functions as an endogenous feedback regulator of calcineurin signal transduction. Forced expression of human MCIP1 protein in the hearts of transgenic mice attenuates the hypertrophic response to a broad range of stimuli. This review summarizes work from a number of laboratories on the structure, regulation, and function of MCIP proteins. (C) 2003 Elsevier Science Inc.

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页码：15 / 21

页数：7

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