Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria

被引：18

作者：

Ban, Shizuka ^{[1
]}

Nakagawa, Hidehiko ^{[1
]}

Suzuki, Takayoshi ^{[1
]}

Miyata, Naoki ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 07期

关键词：

fluorescein; redox; electron spin resonance; reactive oxygen species; superoxide; inflammation;

D O I：

10.1016/j.bmcl.2007.01.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, and apoptosis, are thought to be associated with oxidative stress affecting mitochondria. In this study, we designed and synthesized a fluorescein-tagged TEMPO derivative, compound 1, with triphenylphosphino moiety. Synthesized 1 localized in mitochondria and detected oxidative stress in an endotoxic model of a mouse macrophage-like cell line. Compound 1 is therefore a potentially useful probe for evaluating oxidative stress in mitochondria. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2055 / 2058

页数：4

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