SoxF genes: Key players in the development of the cardio-vascular system

被引：138

作者：

Francois, Mathias ^{[1
]}

Koopman, Peter ^{[1
]}

Beltrame, Monica ^{[2
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[2] Univ Milan, Dipartimento Sci Biomol & Biotecnol, Milan, Italy

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2010年 / 42卷 / 03期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

Sox; Transcription; Development; Cardio-vascular system; Genetics; BOX TRANSCRIPTION FACTOR; REDUNDANT ROLES; VASCULAR DEVELOPMENT; EXPRESSION; MUTATIONS; XENOPUS; SOX-18; SPECIFICATION; LYMPHEDEMA; ZEBRAFISH;

D O I：

10.1016/j.biocel.2009.08.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SoxF genes (Sox7, Sox17 and Sox18) encode a group of transcription factors that have a pivotal role in cardio-vascular development. SOXF factors orchestrate endothelial cell fate or direct cell differentiation in developing heart, blood vessels and lymphatic vessels. Their roles are highly conserved throughout animal evolution. SOXF activity is finely tuned with a variety of cell type-specific co-factors and partner proteins to effect transcription of genes critical for endothelial cell phenotype and function. Because SOXF factors play a central role in cardiogenesis, vasculogenesis and lymphangiogenesis, SOXF gene mutations figure prominently in the aetiology of human vascular disease. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

引用

页码：445 / 448

页数：4

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