Aberrant receptor-mediated Cushing's syndrome

被引：14

作者：

Bertagna, X ^{[1
]}

Groussin, L ^{[1
]}

Luton, JP ^{[1
]}

Bertherat, J ^{[1
]}

机构：

[1] Hop Cochin, Serv Malad Endocriniennes & Metab, F-75014 Paris, France

来源：

HORMONE RESEARCH | 2003年 / 59卷

关键词：

Cushing's syndrome; adrenal tumor; G-protein-coupled receptors;

D O I：

10.1159/000067832

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple alterations of G-protein-coupled receptors and G-proteins regulating intracellular transduction signal have been described in endocrine tumours. In Cushing's syndrome, aberrant or 'illicit' expression of membrane receptors (mainly G-protein-coupled receptors) has been observed in adrenal adenomas and adrenocorticotropic hormone (ACTH)-independent macronodular bilateral adrenal hyperplasia. The best characterized example to date is the aberrant expression of the gastric inhibitory polypeptide receptor that causes 'food-dependent hypercortisolism'. Aberrant expression of the luteinizing hormone, beta(2)-adrenergic, interleukin receptors have also been reported. The level of expression of the vasopressin V1a receptor correlates with the direct (ACTH-independent) cortisol response to vasopressin. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：99 / 103

页数：5

共 20 条

[1] Variable expression of the V1 vasopressin receptor modulates the phenotypic response of steroid-secreting adrenocortical tumors [J].

Arnaldi, G ;

Gasc, JM ;

de Keyzer, Y ;

Raffin-Sanson, ML ;

Perraudin, V ;

Kuhn, JM ;

Raux-Demay, MC ;

Luton, JP ;

Clauser, E ;

Bertagna, X .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (06) :2029-2035

[2] Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: Insights into hormonal control of adrenocortical tumorigenesis [J].

Chabre, O ;

Liakos, P ;

Vivier, J ;

Chaffanjon, P ;

Labat-Moleur, F ;

Martinie, M ;

Bottari, SP ;

Bachelot, I ;

Chambaz, EM ;

Defaye, G ;

Feige, JJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (09) :3134-3143

[3] Food-dependent Cushing's syndrome resulting from abundant expression of gastric inhibitory polypeptide receptors in adrenal adenoma cells [J].

deHerder, WW ;

Hofland, LJ ;

Usdin, TB ;

deJong, FH ;

Uitterlinden, P ;

vanKoetsveld, P ;

Mezey, E ;

Bonner, TI ;

Bonjer, HJ ;

Lamberts, SWJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (09) :3168-3172

[4]

HAMET P, 1987, CLIN INVEST MED, V327, P981

[5] Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome [J].

Lacroix, A ;

N'Diaye, N ;

Tremblay, J ;

Hamet, P .

ENDOCRINE REVIEWS, 2001, 22 (01) :75-110

[6] GASTRIC-INHIBITORY POLYPEPTIDE DEPENDENT CORTISOL HYPERSECRETION - A NEW CAUSE OF CUSHINGS-SYNDROME [J].

LACROIX, A ;

BOLTE, E ;

TREMBLAY, J ;

DUPRE, J ;

POITRAS, P ;

FOURNIER, H ;

GARON, J ;

GARREL, D ;

BAYARD, F ;

TAILLEFER, R ;

FLANAGAN, RJ ;

HAMET, P .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (14) :974-980

[7] Propranolol therapy for ectopic beta-adrenergic receptors adrenal Cushing's syndrome [J].

Lacroix, A ;

Tremblay, J ;

Rousseau, G ;

Bouvier, M ;

Hamet, P .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (20) :1429-1434

[8]

LACROIX A, 1998, 80 ANN M END SOC PRE, P80

[9] GTPASE INHIBITING MUTATIONS ACTIVATE THE ALPHA-CHAIN OF GS AND STIMULATE ADENYLYL CYCLASE IN HUMAN PITUITARY-TUMORS [J].

LANDIS, CA ;

MASTERS, SB ;

SPADA, A ;

PACE, AM ;

BOURNE, HR ;

VALLAR, L .

NATURE, 1989, 340 (6236) :692-696

[10] Food-dependent Cushing's syndrome: Characterization and functional role of gastric inhibitory polypeptide receptor in the adrenals of three patients [J].

Lebrethon, MC ;

Avallet, O ;

Reznik, Y ;

Archambeaud, F ;

Combes, J ;

Usdin, TB ;

Narboni, G ;

Mahoudeau, J ;

Saez, JM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (12) :4514-4519

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