Problems and solutions to the development of vaccines in the elderly

被引:18
作者
Effros, RB [1 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
关键词
D O I
10.1016/S0889-8561(02)00055-3
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
One of the major target populations for vaccination is the ever-increasing cohort of persons aged 65 and older, a group that is characterized by high morbidity and mortality from infections that partly are caused by reduced immune function. Many elderly persons also show suboptimal response to vaccines that are intended to prevent infection. A new immune biomarker of reduced antibody response to vaccination is the presence of a high proportion of memory CD8 T cells that lack expression of the CD28 costimulatory molecule. This article discusses some of the challenges involved in custom-designing vaccines that account for the remodeled immune system of the elderly.
引用
收藏
页码:41 / +
页数:16
相关论文
共 89 条
[1]   Dietary self-selection can compensate an age-related decrease of rat liver 20 S proteasome activity observed with standard diet [J].
Anselmi, B ;
Conconi, M ;
Veyrat-Durebex, C ;
Turlin, E ;
Biville, F ;
Alliot, J ;
Friguet, B .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1998, 53 (03) :B173-B179
[2]   Immune responses and protection in different strains of aged mice immunized intranasally with an adjuvant-combined influenza vaccine [J].
Asanuma, H ;
Hirokawa, K ;
Uchiyama, M ;
Suzuki, Y ;
Aizawa, C ;
Kurata, T ;
Sata, T ;
Tamura, S .
VACCINE, 2001, 19 (28-29) :3981-3989
[3]  
AZUMA M, 1993, J IMMUNOL, V150, P1147
[4]   Efficacy of anti-influenza peptide vaccine in aged mice [J].
Ben-Yedidia, T ;
Abel, L ;
Arnon, R ;
Globerson, A .
MECHANISMS OF AGEING AND DEVELOPMENT, 1998, 104 (01) :11-23
[5]   Cytokine and chemokine gene expression after primary and secondary respiratory syncytial virus infection in cotton rats [J].
Blanco, JCG ;
Richardson, JY ;
Darnell, MER ;
Rowzee, A ;
Pletneva, L ;
Porter, DD ;
Prince, GA .
JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (12) :1780-1785
[6]   Mechanism of telomerase induction during T cell activation [J].
Bodnar, AG ;
Kim, NW ;
Effros, RB ;
Chiu, CP .
EXPERIMENTAL CELL RESEARCH, 1996, 228 (01) :58-64
[7]   Edible vaccines tackle mucosal infections head on [J].
Bonn, D .
LANCET INFECTIOUS DISEASES, 2002, 2 (05) :263-263
[8]   CD28 expression in T cell aging and human longevity [J].
Boucher, N ;
Dufeu-Duchesne, T ;
Vicaut, E ;
Farge, D ;
Effros, RB ;
Schachter, F .
EXPERIMENTAL GERONTOLOGY, 1998, 33 (03) :267-282
[9]   Cellular senescence, cancer and aging: the telomere connection [J].
Campisi, J ;
Kim, SH ;
Lim, CS ;
Rubio, M .
EXPERIMENTAL GERONTOLOGY, 2001, 36 (10) :1619-1637
[10]   Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents [J].
Castle, S ;
Uyemura, K ;
Wong, W ;
Modlin, R ;
Effros, R .
MECHANISMS OF AGEING AND DEVELOPMENT, 1997, 94 (1-3) :7-16