Problems and solutions to the development of vaccines in the elderly

被引：18

作者：

Effros, RB ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2003年 / 23卷 / 01期

关键词：

D O I：

10.1016/S0889-8561(02)00055-3

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

One of the major target populations for vaccination is the ever-increasing cohort of persons aged 65 and older, a group that is characterized by high morbidity and mortality from infections that partly are caused by reduced immune function. Many elderly persons also show suboptimal response to vaccines that are intended to prevent infection. A new immune biomarker of reduced antibody response to vaccination is the presence of a high proportion of memory CD8 T cells that lack expression of the CD28 costimulatory molecule. This article discusses some of the challenges involved in custom-designing vaccines that account for the remodeled immune system of the elderly.

引用

页码：41 / +

页数：16

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