Progression of chronic renal disease

被引：99

作者：

Klahr, S

Morrissey, J

机构：

[1] Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Internal Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 2003年 / 41卷 / 03期

关键词：

angiotensin II; transforming growth factor-beta 1 (TGF-beta 1); tumor necrosis factor-alpha (TNF-alpha); nuclear factor-kappa B (NF-kappa B);

D O I：

10.1053/ajkd.2003.50074

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Risk factors for progression of kidney disease include hypertension, proteinuria, male sex, obesity, diabetes mellitus, hyperlipidemia, smoking, high-protein diets, phosphate retention, and metabolic acidosis. Angiotensin II production upregulates the expression of transforming growth factor-beta1, tumor necrosis factor-a, nuclear factor-kappaB, and several adhesion molecules and chemoattractants. In addition to angiotensin, other vasoactive compounds, such as thromboxane A(2), endothelin, and prostaglandins, are upregulated. Treatment with one of several growth factors may ameliorate the progression of kidney disease: insulin-like growth factor-1, hepatocyte growth factor, and bone morphogenetic protein-7.

引用

收藏

页码：S3 / S7

页数：5

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