Fetal stem cells

被引：120

作者：

O'Donoghue, K

Fisk, NM

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Expt Fetal Med Grp, Inst Reprod & Dev Biol, London W12 0NN, England

[2] Queen Charlottes & Chelsea Hosp, Ctr Fetal Care, London W12 0NN, England

来源：

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | 2004年 / 18卷 / 06期

关键词：

fetal blood progenitors; fetal bone marrow; fetal liver; haemopoietic; mesenchymal;

D O I：

10.1016/j.bpobgyn.2004.06.010

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Fetal stem cells can be isolated from fetal blood and bone marrow as well as from other fetal tissues, including liver and kidney. Fetal blood is a rich source of haemopoietic stem cells (HSC), which proliferate more rapidly than those in cord blood or adult bone marrow. First trimester fetal blood also contains a population of non-haemopoietic mesenchymal stem cells (MSC), which support haemopoiesis and can differentiate along multiple lineages. In terms of eventual downstream application, both fetal HSC and MSC have advantages over their adult counterparts, including better intrinsic homing and engraftment, greater multipotentiality and lower immunogenicity. Fetal stem cells are less ethically contentious than embryonic stem cells and their differentiation potential appears greater than adult stem cells. Fetal stem cells represent powerful tools for exploring many aspects of cell biology and hold considerable promise as therapeutic tools for cell transplantation and ex vivo gene therapy.

引用

收藏

页码：853 / 875

页数：23

相关论文

共 101 条

[1] Stem cells in the kidney [J].

Al-Awqati, Q ;

Oliver, JA .

KIDNEY INTERNATIONAL, 2002, 61 (02) :387-395

[2] An in situ study of CD34+ cells in human fetal bone marrow [J].

Allen, JE ;

Henshaw, DL .

BRITISH JOURNAL OF HAEMATOLOGY, 2001, 114 (01) :201-210

[3] Differentiative potential of human metanephric mesenchymal cells [J].

Almeida-Porada, G ;

El Shabrawy, D ;

Porada, C ;

Zanjani, ED .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (12) :1454-1462

[4]

Anker PSI, 2003, HAEMATOLOGICA, V88, P845

[5] Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum [J].

Bianchi, DW ;

Zickwolf, GK ;

Weil, GJ ;

Sylvester, S ;

DeMaria, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (02) :705-708

[6] INVITRO SENESCENCE OF SYRIAN-HAMSTER MESENCHYMAL CELLS OF FETAL TO AGED ADULT ORIGIN - INVERSE RELATIONSHIP BETWEEN INVIVO DONOR AGE AND INVITRO PROLIFERATIVE CAPACITY [J].

BRUCE, SA ;

DEAMOND, SF ;

TSO, POP .

MECHANISMS OF AGEING AND DEVELOPMENT, 1986, 34 (02) :151-173

[7] Circulating hematopoietic progenitor cells in first trimester fetal blood [J].

Campagnoli, C ;

Fisk, N ;

Overton, T ;

Bennett, P ;

Watts, T ;

Roberts, I .

BLOOD, 2000, 95 (06) :1967-1972

[8] High transduction efficiency of circulating first trimester fetal mesenchymal stem cells:: potential targets for in utero ex vivo gene therapy [J].

Campagnoli, C ;

Bellantuono, I ;

Kumar, S ;

Fairbairn, LJ ;

Roberts, I ;

Fisk, NM .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2002, 109 (08) :952-954

[9] Expandability of haemopoietic progenitors in first trimester fetal and maternal blood: implications for non-invasive prenatal diagnosis [J].

Campagnoli, C ;

Roberts, IAG ;

Kumar, S ;

Choolani, M ;

Bennett, PR ;

Letsky, E ;

Fisk, NM .

PRENATAL DIAGNOSIS, 2002, 22 (06) :463-469

[10] Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow [J].

Campagnoli, C ;

Roberts, IAG ;

Kumar, S ;

Bennett, PR ;

Bellantuono, I ;

Fisk, NM .

BLOOD, 2001, 98 (08) :2396-2402

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