Electron-transfer processes of cytochrome c at interfaces.: New insights by surface-enhanced resonance Raman spectroscopy

被引：202

作者：

Murgida, DH ^{[1
]}

Hildebrandt, P ^{[1
]}

机构：

[1] Tech Univ Berlin, Inst Chem, Max Volmer Lab Biophys Chem, D-10623 Berlin, Germany

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2004年 / 37卷 / 11期

关键词：

D O I：

10.1021/ar0400443

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The heme protein cytochrome c acts as an electron carrier at the mitochondrial-membrane interface and thus exerts its function under the influence of strong electric fields. To assess possible consequences of electric fields on the redox processes of cytochrome c, the protein can be immobilized to self-assembled monolayers on electrodes and studied by surface-enhanced resonance Raman spectroscopy. Such model systems may mimic some essential features of biological interfaces including local electric field strengths. It is shown that physiologically relevant electric field strengths can effectively modulate the electron-transfer dynamics and induce conformational transitions.

引用

页码：854 / 861

页数：8

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