Multiple Epstein-Barr virus infections in healthy individuals

被引：84

作者：

Walling, DM

Brown, AL

Etienne, W

Keitel, WA

Ling, PD

机构：

[1] Univ Texas, Div Infect Dis, Dept Internal Med, Med Branch, Galveston, TX 77555 USA

[2] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[3] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 11期

关键词：

D O I：

10.1128/JVI.77.11.6546-6550.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We employed a newly developed genotyping technique with direct representational detection of LMP-1 gene sequences to study the molecular epidemiology of Epstein-Barr virus (EBV) infection in healthy individuals. Infections with up to five different EBV genotypes were found in two of nine individuals studied. These results support the hypothesis that multiple EBV infections of healthy individuals are common. The implications for the development of an EBV vaccine are discussed.

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页码：6546 / 6550

页数：5

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