Involvement of an efflux system in high-level fluoroquinolone resistance of Shigella dysenteriae

被引：37

作者：

Ghosh, AS ^{[1
]}

Ahamed, J ^{[1
]}

Chauhan, KK ^{[1
]}

Kundu, M ^{[1
]}

机构：

[1] Univ Calcutta, Dept Chem, Bose Inst, Calcutta 700009, W Bengal, India

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 242卷 / 01期

关键词：

D O I：

10.1006/bbrc.1997.7902

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Shigella dysenteriae represent one of the growing list of antibiotic-resistant bacteria. Quinolones are widely employed to treat shigellosis. However, quinolone resistance has already been reported, necessitating an understanding of the mechanisms of development of resistance, We demonstrate that high-level fluoroquinolone resistance of S. dysenteriae exposed to these antibiotics may occur in the absence of gyrA mutations and involve a proton motive force(pmf)-dependent efflux system. (C) 1998 Academic Press.

引用

页码：54 / 56

页数：3

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