Historical review: Viruses, crystals and geodesic domes

被引：22

作者：

Morgan, GJ ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Philosophy, Baltimore, MD 21218 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0968-0004(02)00007-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the mid 1950s, Francis Crick and James Watson attempted to explain the structure of spherical viruses. They hypothesized that spherical viruses consist of 60 identical equivalently situated subunits. Such an arrangement has icosahedral symmetry. Subsequent biophysical and electron micrographic data suggested that many viruses had >60 subunits. Drawing inspiration from architecture, Donald Caspar and Aaron Klug discovered a solution to the problem - they proposed that spherical viruses were structured like miniature geodesic domes.

引用

页码：86 / 90

页数：5

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