Activation of HOX11L2 by juxtaposition with 3′-BCL11B in an acute lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2)

被引：43

作者：

MacLeod, RAF

Nagel, S

Kaufmann, M

Janssen, JWG

Drexler, HG

机构：

[1] DSMZ, German Collect Microorganisms & Cell Cultures, Dept Cell Cultures, Braunschweig, Germany

[2] Univ Heidelberg, Inst Human Genet, Heidelberg, Germany

来源：

GENES CHROMOSOMES & CANCER | 2003年 / 37卷 / 01期

关键词：

D O I：

10.1002/gcc.10194

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis of a pediatric T-cell acute lymphoblastic leukemia (ALL) cell line (HPB-ALL) revealed the cryptic t(5;14)(q35;q32.2), recently found in 15-20% pediatric T-ALL patients, with 5q35 and 14q32.2 breakpoints at 5'-HOXIIL2 and 3'-BCLIIB, respectively. Expression of both BCLIIB, which is hematologically restricted to T cells, and HOXIIL2 was detected, whereas adjacent genes at 5q35 17) and 14q32 (VRKI, HSU88895) were not dysregulated. Apparently, t(5;14)(q35; q32.2) serves to activate HOXIIL2 by juxtaposition with elements downstream of BCLIIB, implying a novel dysregulatory mechanism comparable to TCRA/D or IGH juxtaposition. As well as providing molecular cytogenetic documentation of t(5; 14) ALL, this report validates HPB-ALL cells for investigating this important new disease entity in vitro. (C) 2003 Wiley-Liss, Inc.

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页码：84 / 91

页数：8

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