Exosomes from human adipose-derived stem cells promote proliferation and migration of skin fibroblasts

被引：171

作者：

Choi, Eun Wook ^{[1
]}

Seo, Min Koo ^{[1
]}

Woo, Eun Young ^{[1
]}

Kim, Suk Hyung ^{[1
]}

Park, Eun Joo ^{[1
]}

Kim, Sue ^{[1
]}

机构：

[1] Prostem Res Inst, Seoul, South Korea

来源：

EXPERIMENTAL DERMATOLOGY | 2018年 / 27卷 / 10期

关键词：

extracellular vesicle; microRNA array; skin regeneration; wound healing; SECRETORY FACTORS;

D O I：

10.1111/exd.13451

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

This study was undertaken to evaluate whether exosomes from human adipose-derived stem cells (ASC-exo) can stimulate the regeneration of human dermal fibroblasts (HDFs). Immunoblotting and FACS analyses showed that ASC-exo was positive for exosome markers. Fluorescence tracking revealed that the contents of ASC-exo were transferred into the HDFs. ASC-exo treatment also stimulated the proliferation and migration of HDFs in a dose-dependent manner. Similarly, the expression levels of genes involved in skin cell proliferation were increased by ASC-exo. Microarray analysis showed an enrichment of microRNAs that have regenerative function. We suggest that the ASC-exo can stimulate skin cell proliferation.

引用

页码：1170 / 1172

页数：3

共 9 条

[1]

Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts [J].