Workgroup report:: Incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies

被引:129
作者
Coecke, Sandra
Goldberg, Alan M.
Allen, Sandra
Buzanska, Leonora
Calamandrei, Gemma
Crofton, Kevin
Hareng, Lars
Hartung, Thomas
Knaut, Holger
Honegger, Paul
Jacobs, Miriam
Lein, Pamela
Li, Abby
Mundy, William
Owen, David
Schneider, Steffen
Silbergeld, Ellen
Reum, Torsten
Trnovec, Tomas
Monnet-Tschudi, Florianne
Bal-Price, Anna
机构
[1] Inst Hlth & Consumer Protect, European Commiss Joint Res Ctr, Ispra, Italy
[2] Johns Hopkins Univ, Ctr Alternat Anim Testing, Baltimore, MD USA
[3] Syngenta CTL, Macclesfield, Cheshire, England
[4] Polish Acad Sci, Warsaw, Poland
[5] Ist Super Sanita, I-00161 Rome, Italy
[6] US EPA, Res Triangle Pk, NC 27711 USA
[7] NYU, Sch Med, New York, NY USA
[8] Univ Lausanne, Lausanne, Switzerland
[9] Oregon Hlth & Sci Univ, Portland, OR 97201 USA
[10] CEFIC, European Chem Ind Council, Shell Chem Ltd, London, England
[11] Slovask Med Univ, Bratislava, Slovakia
关键词
high-throughput screening; in vitro developmental neurotoxicity models; regulatory use; validation;
D O I
10.1289/ehp.9427
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
This is the report of the first workshop on Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment Strategies, held in Ispra, Italy, on 19-21 April 2005. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and jointly organized by ECVAM, the European Chemical Industry Council, and the Johns Hopkins University Center for Alternatives to Animal Testing. The primary aim of the workshop was to identify and catalog potential methods that could be used to assess how data from in vitro alternative methods could help to predict and identify DNT hazards. Working groups focused on two different aspects: a) details on the science available in the field of DNT, including discussions on the models available to capture the critical DNT mechanisms and processes, and b) policy and strategy aspects to assess the integration of alternative methods in a regulatory framework. This report summarizes these discussions and details the recommendations and priorities for future work.
引用
收藏
页码:924 / 931
页数:8
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