Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry

被引：44

作者：

Patterson, S ^{[1
]}

Smith, BD ^{[1
]}

Taylor, RE ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 20期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(98)00514-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Combinatorial libraries of carbohydrate receptors were produced by first derivatizing poly(allylamine) with the fluorescent boronic acid 1 followed by various mixtures of carboxylic acids. The libraries were screened for members that exhibited a larger response for sialic acid than glucose or fructose. The derivatized polymers appear to bind sialic acid by a cooperative mechanism. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3111 / 3114

页数：4

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