Mild cognitive impairment in symptomatic and asymptomatic cerebrovascular disease

被引:89
作者
Popovic, Irena Martinic [1 ]
Seric, Vesna [1 ]
Demarin, Vida [1 ]
机构
[1] Univ Zagreb, Univ Dept Neurol, Sestre Milosrdnice Univ Hosp, HR-10000 Zagreb, Croatia
关键词
brain-pathology; brain-physiopathology; cerebrovascular disease-diagnostics; dementia-Alzheimer's disease; dementia-vascular dementia;
D O I
10.1016/j.jns.2007.01.029
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We tried to evaluate and to compare usefulness of two brief cognitive tests in early detection of cognitive decline in subjects with increased cerebrovascular (CV) risk. As CV risk factors are recognised as important in etiology of dementia, we also aimed to determine the possible associations of specific CV risk factors and cognitive results. Patients (PGs) with first-ever stroke or TIA (N=110) and CV symptoms-free controls (CGs) with CV risk factors present (N=45) matched for age, gender and education level were tested using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) on admission, at three- and six-month points. In all subjects, detailed CV risk factors profile was assessed. We observed the decrement in cognitive performance during the six-month study period in both groups, more evident if MoCA (p < 0.001) than if MMSE was used (p=0.022). Six months after first stroke/TIA 83.6% PGs scored below normal range on MoCA. In PGs, positive associations for cognitive decrement and multiple CV risk factors (> 2) were found (p=0.034 for MMSE; p=0.002 for MoCA). In CGs, positive associations were found for cognitive decrement and arterial hypertension with increased IMT values (p < 0.001 for MMSE) and for multiple CV risk factors and arterial hypertension (p=0.003 for MoCA). The use of MoCA could aid to early recognition of cognitive deficits in persons with increased CV risk. Individuals with multiple CV risk factors seem to have increased risk of cognitive decline. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:185 / 193
页数:9
相关论文
共 50 条
  • [1] NON-INVASIVE TRANSCRANIAL DOPPLER ULTRASOUND RECORDING OF FLOW VELOCITY IN BASAL CEREBRAL-ARTERIES
    AASLID, R
    MARKWALDER, TM
    NORNES, H
    [J]. JOURNAL OF NEUROSURGERY, 1982, 57 (06) : 769 - 774
  • [2] Transient ischemic attack - Proposal for a new definition.
    Albers, GW
    Caplan, LR
    Easton, JD
    Fayad, PB
    Mohr, JP
    Saver, JL
    Sherman, DG
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (21) : 1713 - 1716
  • [3] ALEXANDROV AV, 1999, ACTA CLIN CROAT, V38, P97
  • [4] Poststroke dementia -: Clinical features and risk factors
    Barba, R
    Martínez-Espinosa, S
    Rodríguez-García, E
    Pondal, M
    Vivancos, J
    Del Ser, T
    [J]. STROKE, 2000, 31 (07) : 1494 - 1501
  • [5] Blood pressure, cognitive functions, and prevention of dementias in older patients with hypertension
    Birkenhäger, WH
    Forette, F
    Seux, ML
    Wang, JG
    Staessen, JA
    [J]. ARCHIVES OF INTERNAL MEDICINE, 2001, 161 (02) : 152 - 156
  • [6] Common carotid intima-media thickness and risk of stroke and myocardial infarction - The Rotterdam Study
    Bots, ML
    Hoes, AW
    Koudstaal, PJ
    Hofman, A
    Grobbee, DE
    [J]. CIRCULATION, 1997, 96 (05) : 1432 - 1437
  • [7] BOWLER JV, 2003, VASCULAR COGNITIVE I, P231
  • [8] BOWLER JV, 2002, VASCULAR COGNITIVE I, P9
  • [9] Mild cognitive impairment
    Chertkow, H
    [J]. CURRENT OPINION IN NEUROLOGY, 2002, 15 (04) : 401 - 407
  • [10] DESMOND DW, 2002, VASCULAR COGNITIVE I, P323