The immediate-early gene product MAD-3/EDG-3/I kappa B alpha is an endogenous modulator of fibroblast growth factor-1 (FGF-1) dependent human endothelial cell growth

被引：7

作者：

Hla, T ^{[1
]}

Zimrin, AB ^{[1
]}

Evans, M ^{[1
]}

Ballas, K ^{[1
]}

Maciag, T ^{[1
]}

机构：

[1] AMER RED CROSS,HOLLAND LAB,DEPT MOL BIOL,ROCKVILLE,MD 20855

来源：

FEBS LETTERS | 1997年 / 414卷 / 02期

关键词：

angiogenesis; NF kappa B; I kappa B; fibroblast growth factor; endothelium;

D O I：

10.1016/S0014-5793(97)01053-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tumor promoter phorbol 12-myristic 13-acetate inhibits the growth of human endothelial cells and induces the formation of capillary-like, tubular structures. We report the novel growth regulatory function of the immediate-early gene, edg-3, which is identical to the I kappa B alpha/MAD-3 gene. We employed phosphothioate oligonucleotides (PTO) directed against the translation initiation site of I kappa B alpha to inhibit its expression. The antisense I kappa B alpha PTO-treated cells exhibited an exaggerated growth response to fibroblast growth factor-1 (FGF-1). In contrast, IL-1-induced growth arrest response was not modulated. These data suggest that the early response gene I kappa B alpha is an endogenous regulator of endothelial cell growth in vitro. (C) 1997 Federation of European Biochemical Societies.

引用

页码：419 / 424

页数：6

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