Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex

被引：106

作者：

Zamir, I

Dawson, J

Lavinsky, RM

Glass, CK

Rosenfeld, MG

Lazar, MA

机构：

[1] Univ Penn, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

[3] Univ Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA

[6] Univ Calif San Diego, Grad Program Biol, La Jolla, CA 92093 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 26期

关键词：

D O I：

10.1073/pnas.94.26.14400

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nuclear hormone receptors are potent repressors of transcription in the unliganded state, We describe here the cloning of a nuclear receptor corepressor that we call SUN-CoR (Small Unique Nuclear receptor CoRepressor), which shows no homology to previously described nuclear hormone receptor corepressors, N-CoR or SMRT, SUN-CoR is a highly basic, 16-kDa nuclear protein that is expressed at high levels in adult tissues and is induced during adipocyte and myogenic differentiation. SUN-CoR potentiates transcriptional repression by thyroid hormone receptor and RevErb in vivo, represses transcription when fused to a heterologous DNA binding domain, and interacts with RevErb as well as with thyroid hormone receptor in vitro, SUN-CoR also interacts with N-CoR and SMRT in vitro and with endogenous N-CoR in cells, We conclude that SUN-CoR is a corepressor and may function as an additional component of the complex involved in transcriptional repression by unliganded and orphan nuclear hormone receptors.

引用

页码：14400 / 14405

页数：6

共 31 条

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