DNA methylation as a target for drug design

被引：83

作者：

Bender, CM ^{[1
]}

Zingg, JM ^{[1
]}

Jones, PA ^{[1
]}

机构：

[1] Univ So Calif, Sch Med, Norris Comprehens Canc Ctr, Urol Canc Res Lab, Los Angeles, CA 90033 USA

来源：

PHARMACEUTICAL RESEARCH | 1998年 / 15卷 / 02期

关键词：

DNA methylation; 5-methylcytosine; cancer; 5-Aza-2 '-deoxycytidine;

D O I：

10.1023/A:1011946030404

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA methylation is essential for normal embryonic development. Distinctive genomic methylation patterns must be formed and maintained with high fidelity to ensure the inactivities of specific promoters during development. The mutagenic and epigenetic aspects of DNA methylation are especially interesting because they may lead to the inactivation of genes which are involved in human carcinogenesis. The mutagenicity of 5-Methylcytosine (5mC) and the role of promoter hypermethylation in gene silencing, particularly in cancer, suggest a clinical significance for the design of novel DNA methylation inhibitors which may be utilized to reverse the effects of DNA methylation.

引用

页码：175 / 187

页数：13

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