Secretion of human tau fragments resembling CSF-tau in Alzheimer's disease is modulated by the presence of the exon 2 insert

被引：61

作者：

Kim, WonHee ^{[1
]}

Lee, Sangmook ^{[1
]}

Hall, Garth F. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Biol Sci, Ctr Cellular Neurosci & Neurodegenerat Res, Lowell, MA 01854 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 14期

关键词：

Tau; Tau secretion; Cerebrospinal fluid; Proteolysis; Exon; 2; Cellular model; PROGRESSIVE SUPRANUCLEAR PALSY; CEREBROSPINAL-FLUID; NEUROFIBRILLARY DEGENERATION; CORTICOBASAL DEGENERATION; NEURONAL CELLS; ISOFORMS; CLEAVAGE; PROTEIN; TAUOPATHIES; BRAIN;

D O I：

10.1016/j.febslet.2010.05.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abnormal tau cleavage is prominent in the neurofibrillary degeneration characteristic of Alzheimer's disease (AD) and related tauopathies. We recently showed that cleaved human tau is secreted by specific mechanisms when overexpressed. Here we examined the effect of expressing N-terminal and full length tau constructs in transiently and stably transfected neuronal lines. We show that secreted tau exhibits a cleavage pattern similar to CSF-tau from human AD patients and that tau secretion is specifically inhibited by the presence of the exon 2 insert. These results suggest that tau secretion may play a hitherto unsuspected role in AD and related tauopathies. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：3085 / 3088

页数：4

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